The epicardium as a hub for heart regeneration
نویسندگان
چکیده
منابع مشابه
Cardiac Regeneration from Activated Epicardium
In contrast to lower vertebrates, the mammalian heart has a very limited regenerative capacity. Cardiomyocytes, lost after ischemia, are replaced by fibroblasts. Although the human heart is able to form new cardiomyocytes throughout its lifespan, the efficiency of this phenomenon is not enough to substitute sufficient myocardial mass after an infarction. In contrast, zebrafish hearts regenerate...
متن کاملEpicardium-Derived Heart Repair
In the last decade, cell replacement therapy has emerged as a potential approach to treat patients suffering from myocardial infarction (MI). The transplantation or local stimulation of progenitor cells with the ability to form new cardiac tissue provides a novel strategy to overcome the massive loss of myocardium after MI. In this regard the epicardium, the outer layer of the heart, is a tract...
متن کاملApproaches to augment vascularisation and regeneration of the adult heart via the reactivated epicardium
Survival rates following myocardial infarction have increased in recent years but current treatments for post-infarction recovery are inadequate and cannot induce regeneration of damaged hearts. Regenerative medicine could provide disease-reversing treatments by harnessing modern concepts in cell and developmental biology. A recently-established paradigm in regenerative medicine is that regener...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولA hand for the epicardium.
In mammals, formation of the properly septated 4-chambered heart and coronary vasculature is essential for unidirectional blood flow and survival of the organism. This process involves complex cell-cell interactions, the dysregulation of which can profoundly alter organogenesis, leading to a plethora of structural or functional cardiac defects. No wonder that congenital heart disease (CHD) repr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cardiology
سال: 2018
ISSN: 1759-5002,1759-5010
DOI: 10.1038/s41569-018-0046-4